Preimplantation Genetic Screening with aCGH (array Comparative Genetic Hybridization) technology. Array-CGH is used extensively worldwide, and it was the first technology to be widely available for analysis of chromosomal abnormalities in the embryo. This screening is also called aneuploidy testing: counting the number of chromosomes present in a cell. If a cell does not have exactly 46 chromosomes, it is aneuploid. Embryo with healthy set of chromosome called euploid. aCGH testing of embryos allows us to determine the number of chromosomes in each embryo before they are transferred into the mother’s uterus.
aCGH chromosome screening offers much more precise information than standard genetic testing has in the past. During CGH testing all chromosomes including X and Y are analyzed and compared to a sample of “normal” DNA. The advantage of doing aCGH testing over traditional testing is that all 23 pairs of chromosomes can be tested and the results are more accurate when testing for aneuploidy.