Science behind Ovarian Rejuvenation with PRP
PRP comprises many proteins, such as cytokines, hormones, and most importantly growth factors. These factors, which are concentrated in PRP following centrifugation, include platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF), epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-I), and 2 (IGF-II). All these growth factors are considered responsible for cell migration and differentiation, and for proliferation, activation of angiogenesis, and tissue regeneration.
Interestingly, studies have reported a correlation between aging and decreased concentrations of growth hormone and IGF-1.
Although still considered experimental and has yet to be established routine clinical status, it is established as a very promising option in addressing ovarian insufficiency.
Despite the reported encouraging results, an all-inclusive report on PRP’s clinical, cellular, and molecular regenerative dynamics on the reproductive system still eludes us.
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