

Mini IVF (Minimal Stimulation IVF) is an IVF approach designed to prioritize egg quality, safety, comfort, and thoughtful outcomes—using significantly less medication than conventional IVF. At Hanabusa IVF, Mini IVF is grounded in authentic Japanese mild-stimulation principles: support the body’s natural selection, recruit a small number of follicles, and focus on creating the strongest possible embryos without overstimulation. For many patients—especially those with diminished ovarian reserve (DOR), fertility after 40, or those who prefer a lower-burden IVF experience—Mini IVF can offer a more body-respecting path forward.
Diminished Ovarian Reserve (DOR) + Minimal Stimulation IVF
Description: For patients with diminished ovarian reserve, Minimal Stimulation IVF focuses on retrieving a few high-quality eggs with lower medication and a plan tailored to your biology—because “more” isn’t always better.

Clarify your goals, timeline, and diagnosis
Review ovarian reserve markers (AMH, FSH/E2, AFC) and cycle patterns
Analyze prior IUI/IVF cycles (response, maturity, fertilization, embryo outcomes)
Identify any factors that may change the plan (uterine, tubal, sperm, endometriosis history)
Baseline ultrasound (AFC, ovarian appearance, uterine lining/structure)
Baseline labs to confirm readiness and guide dosing/timing
Safety checks as needed based on your care plan
Build a mild stimulation plan tailored to your biology
Set a monitoring schedule with clear decision points
Define trigger strategy to optimize egg maturity and timing
Begin low-med stimulation (typically fewer injections)
Ultrasounds (and labs when needed) to track follicle growth
Adjust medication and timing based on how you respond
Trigger given when follicles reach the right stage for maturity
Egg retrieval timed precisely (often lower complexity with fewer follicles)
Fertilization via IVF or ICSI as indicated
Embryo culture and development monitoring
Blastocyst culture when appropriate, based on your embryo plan
Decide on transfer timing based on uterine readiness and treatment goals
Often freeze embryos and plan a timed FET when the uterine environment is optimal
Single embryo transfer planning when transfer is the next best step

You have diminished ovarian reserve (DOR) or are concerned about overmedicating
You’re 40+ and want a quality-first approach
You’ve had poor response or poor egg/embryo quality in higher-dose IVF cycles
You prefer fewer injections, fewer monitoring visits, and a lower-burden experience
You’re looking for a thoughtful IVF option that prioritizes safety and comfort
Your evaluation suggests you’re likely to produce a strong egg yield safely with conventional IVF
You need embryo numbers quickly for family size planning (we’ll advise based on your goals)
Your medical history indicates a different protocol would be more effective

Medication needs (often fewer injections, which can lower medication cost)
Monitoring needs (varies by patient response and timing)
Retrieval/anesthesia approach
Fertilization method (IVF vs. ICSI)
Embryo culture, freezing (vitrification), and storage
Whether you proceed with FET
Often included: retrieval procedure + embryo culture (basic lab services)
Often separate: medications, labs, ultrasounds, donor sperm costs, additional testing

Mini IVF success depends on matching the approach to the right patient. The goal is not the most eggs—it’s the best chance of creating a healthy embryo and transferring into the right uterine environment.
Age and ovarian reserve (AMH, FSH, AFC)
Egg maturity and embryo development
Sperm factors and fertilization method
Uterine factors and transfer timing (fresh vs. frozen)
Prior IVF history and response patterns
Embryo transfer strategy (single embryo transfer planning)

Monitoring visits are typically fewer, but still precise and important
Outpatient procedure; recovery is often easier due to fewer follicles
Fertilization and embryo development updates over several days
Often involves frozen transfer planning to optimize the uterine environment, with minimal medication support when appropriate
Mini IVF is a mild stimulation IVF approach designed to retrieve a small number of high-quality eggs using lower medication doses than conventional IVF.
Conventional IVF often aims for a higher egg count using higher medication doses. Mini IVF aims for fewer eggs with a quality-first strategy and typically less medication burden.
Many Mini IVF cycles aim for a small cohort (often a few eggs), but the goal is the healthiest response for your body—not a specific number.
In many cases, yes. Because stimulation is milder, the risk of OHSS may be lower compared to higher-dose stimulation cycles, though risk depends on individual response.
It can be, especially if medication needs are lower. Total cost varies based on monitoring, lab services, fertilization method, freezing, and whether you do FET.
Often fewer. Many protocols use oral medication plus a limited number of low-dose injections, depending on your ovarian response.
Sometimes. If the uterine environment isn’t ideal for transfer in the same cycle, freezing embryos (vitrification) and transferring later can support better outcomes.
It can be a strong fit for patients with DOR, fertility after 40, prior over-response/side effects, or anyone seeking a safer, lower-burden IVF approach.
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You’re a fit for Traditional Fertility Care if any of these statements resonate with you:
You’re just getting started
You want clear first steps
You’ve explored clinics, but still feel at the beginning
You need fertility testing
Your labs look reassuring
Your situation feels straightforward
You have fewer complicating factors
You’re considering IUI
You’re new to IVF
You’re planning an FET
You’re considering PGT
If anything, complex becomes evident, we smoothly upgrade your pathway.
You’re a fit for Complex Care if any of these statements resonate with you:
Low AMH/AFC or DOR concerns
You have Diminished Ovarian Reserve (DOR)
You have POI or high FSH concerns
You’re considering Ovarian Rejuvenation (PRP)
Age 40+ or time feels limited
Prior IVF didn’t respond as hoped
Low egg numbers / embryo growth issues
Unsuccessful embryo transfers
Recurrent pregnancy loss (2+ losses)
Male factor needs ICSI or TESE
You’ve been told your case is complex
If your case is complex from the start, we build the right strategy from day one.